abstract：:Geogenic dust from arid environments is a possible inhalation hazard for humans, especially when using off-road vehicles that generate significant dust. This study focused on immunotoxicological and neurotoxicological effects following subacute exposure to geogenic dust generated from sediments in the Nellis Dunes Rec...

journal_title：Toxicology and applied pharmacology

authors： DeWitt J,Buck B,Goossens D,Hu Q,Chow R,David W,Young S,Teng Y,Leetham-Spencer M,Murphy L,Pollard J,McLaurin B,Gerads R,Keil D

更新日期：2016-08-01 00:00:00

abstract：:The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal models of obesity suggest that CAR activation could be beneficial on the metabolic balance. However, this remains controversial and the underlying mechanisms are sti...

journal_title：Toxicology and applied pharmacology

authors： Marmugi A,Lukowicz C,Lasserre F,Montagner A,Polizzi A,Ducheix S,Goron A,Gamet-Payrastre L,Gerbal-Chaloin S,Pascussi JM,Moldes M,Pineau T,Guillou H,Mselli-Lakhal L

更新日期：2016-07-15 00:00:00

abstract：:Colon cancer is the third most incident type of cancer worldwide. One of the most important risk factors for colon cancer development are inflammatory bowel diseases (IBD), thus therapies focusing on IBD treatment have great potential to be used in cancer prevention. Nature has been a source of new therapeutic and pre...

journal_title：Toxicology and applied pharmacology

authors： Vendramini-Costa DB,Alcaide A,Pelizzaro-Rocha KJ,Talero E,Ávila-Román J,Garcia-Mauriño S,Pilli RA,de Carvalho JE,Motilva V

更新日期：2016-06-01 00:00:00

abstract：:It has been recently recognized that the gut microbiota, the community of organisms living within the gastrointestinal tract is an integral part of the human body, and that its genoma (the microbiome) interacts with the genes expressed by the cells of the host organism. Several important physiological functions requir...

journal_title：Toxicology and applied pharmacology

authors： Pietroiusti A,Magrini A,Campagnolo L

更新日期：2016-05-15 00:00:00

abstract：:Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive resear...

journal_title：Toxicology and applied pharmacology

authors： Riebeling C,Wiemann M,Schnekenburger J,Kuhlbusch TA,Wohlleben W,Luch A,Haase A

更新日期：2016-05-15 00:00:00

abstract：:Engineered nanomaterials are being developed for a variety of technological applications. However, the increasing use of nanomaterials in society has led to concerns about their potential adverse effects on human health and the environment. During the first decade of nanotoxicological research, the realization has eme...

journal_title：Toxicology and applied pharmacology

authors： Costa PM,Fadeel B

更新日期：2016-05-15 00:00:00

abstract：:The popularity of hair dyes use has been increasing regularly throughout the world as per the demand of hair coloring fashion trends and other cosmetic products. 2-Amino-3-hydroxypyridine (A132) is widely used as a hair dye ingredient around the world. We are reporting first time the phototoxicity mechanism of A132 un...

journal_title：Toxicology and applied pharmacology

authors： Goyal S,Amar SK,Dwivedi A,Mujtaba SF,Kushwaha HN,Chopra D,Pal MK,Singh D,Chaturvedi RK,Ray RS

更新日期：2016-04-15 00:00:00

abstract：:The glutathione precursor N-acetyl-L-cysteine (NAC) is currently being tested on Parkinson's patients for its neuroprotective properties. Our studies have shown that NAC can elicit protection in glutathione-independent manners in vitro. Thus, the goal of the present study was to establish an animal model of NAC-mediat...

journal_title：Toxicology and applied pharmacology

authors： Nouraei N,Zarger L,Weilnau JN,Han J,Mason DM,Leak RK

更新日期：2016-04-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) is a critical stage during the development of silicosis fibrosis. In the current study, we hypothesized that the anti-fibrotic tetrapeptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) may exert its anti-fibrotic effects via activation of the TGF-β1/ROCK1 pathway, leadin...

journal_title：Toxicology and applied pharmacology

authors： Deng H,Xu H,Zhang X,Sun Y,Wang R,Brann D,Yang F

更新日期：2016-03-01 00:00:00

abstract：:The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transfo...

journal_title：Toxicology and applied pharmacology

authors： Wu F,Jordan A,Kluz T,Shen S,Sun H,Cartularo LA,Costa M

更新日期：2016-02-15 00:00:00

abstract：:Gossypol, a polyphenolic compound isolated from cottonseeds, has been reported to possess many pharmacological activities, but whether it can influence inflammasome activation remains unclear. In this study, we found that in mouse macrophages, gossypol induced cell death characterized by rapid membrane rupture and rob...

journal_title：Toxicology and applied pharmacology

authors： Lin QR,Li CG,Zha QB,Xu LH,Pan H,Zhao GX,Ouyang DY,He XH

更新日期：2016-02-01 00:00:00

abstract：:Oxidative stress is involved in hepatic stellate cells (HSCs) activation and extracellular matrix overproduction. We previously reported the promising effects of dioscin against CCl4-induced liver fibrosis, but its effects and mechanisms on BDL- and DMN-induced liver fibrosis remain unknown. The results in the present...

journal_title：Toxicology and applied pharmacology

authors： Gu L,Tao X,Xu Y,Han X,Qi Y,Xu L,Yin L,Peng J

更新日期：2016-02-01 00:00:00

abstract：:Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of Health and Disease (DOHaD) concept. Several environmental contaminants have been implicated as modifying factors of the developing epigenome. This underlines the ne...

journal_title：Toxicology and applied pharmacology

authors： Bouwmeester MC,Ruiter S,Lommelaars T,Sippel J,Hodemaekers HM,van den Brandhof EJ,Pennings JL,Kamstra JH,Jelinek J,Issa JP,Legler J,van der Ven LT

更新日期：2016-01-15 00:00:00

abstract：:Morphine may induce cardioprotection by targeting mitochondria, but little is known about the exact mitochondrial events that mediate morphine's protection. We aimed to address the role of the mitochondrial Src tyrosine kinase in morphine's protection. Isolated rat hearts were subjected to 30 min ischemia and 2h of re...

journal_title：Toxicology and applied pharmacology

authors： He H,Huh J,Wang H,Kang Y,Lou J,Xu Z

更新日期：2016-01-01 00:00:00

abstract：:Follicle growth culminates in ovulation, which allows for the expulsion of fertilizable oocytes and the formation of corpora lutea. Bisphenol A (BPA) is present in many consumer products, and it has been suggested that BPA impairs ovulation; however, the underlying mechanisms are unknown. Therefore, this study first e...

journal_title：Toxicology and applied pharmacology

authors： Moore-Ambriz TR,Acuña-Hernández DG,Ramos-Robles B,Sánchez-Gutiérrez M,Santacruz-Márquez R,Sierra-Santoyo A,Piña-Guzmán B,Shibayama M,Hernández-Ochoa I

更新日期：2015-12-15 00:00:00

abstract：:4-Hydroxy-2-trans-nonenal (4HNE), one of the major end products of lipid peroxidation (LPO), has been shown to induce apoptosis in a variety of cell lines. It appears to modulate signaling processes in more than one way because it has been suggested to have a role in signaling for differentiation and proliferation. It...

journal_title：Toxicology and applied pharmacology

authors： Singhal SS,Singh SP,Singhal P,Horne D,Singhal J,Awasthi S

更新日期：2015-12-15 00:00:00

abstract：:We have recently demonstrated that 19-hydroxyeicosatetraenoic acid (19-HETE) is the major subterminal-HETE formed in the heart tissue, and its formation was decreased during cardiac hypertrophy. In the current study, we examined whether 19-HETE confers cardioprotection against angiotensin II (Ang II)-induced cardiac h...

journal_title：Toxicology and applied pharmacology

authors： Elkhatali S,El-Sherbeni AA,Elshenawy OH,Abdelhamid G,El-Kadi AO

更新日期：2015-12-15 00:00:00

abstract：:This study sought to investigate the effects of environmentally relevant gestational followed by continued chronic exposure to the herbicide, atrazine, on motor function, cognition, and neurochemical indices of nigrostriatal dopamine (DA) activity in male rats. Dams were treated with 100 μg/kg atrazine, 10mg/kg atrazi...

journal_title：Toxicology and applied pharmacology

authors： Walters JL,Lansdell TA,Lookingland KJ,Baker LE

更新日期：2015-12-01 00:00:00

abstract：:Anoikis is defined as apoptosis, which is induced by inappropriate cell-matrix interactions. Cancer cells with anoikis resistance tend to undergo metastasis, and this phenomenon has been reported to be associated with integrin and FAK activity. HPW-RX40 is a derivative of 3,4-methylenedioxy-β-nitrostyrene, which is kn...

journal_title：Toxicology and applied pharmacology

authors： Chen IH,Shih HC,Hsieh PW,Chang FR,Wu YC,Wu CC

更新日期：2015-12-01 00:00:00

abstract：:As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the m...

journal_title：Toxicology and applied pharmacology

authors： Wang XX,Lv X,Li SY,Hou J,Ning J,Wang JY,Cao YF,Ge GB,Guo B,Yang L

更新日期：2015-11-15 00:00:00

abstract：:Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds. These compounds stimulate the development of steatohepatitis through their toxicity to hepatocyte mitochondria; inhibition of beta-oxidation, mitochondrial respiration, and/or oxidative phosphorylation. Other...

journal_title：Toxicology and applied pharmacology

authors： Schumacher JD,Guo GL

更新日期：2015-11-15 00:00:00

abstract：:Subchronic and chronic studies in rats of the gasoline oxygenates ethyl tert-butyl ether (ETBE) and tert-butanol (TBA) report similar noncancer kidney and liver effects but differing results with respect to kidney and liver tumors. Because TBA is a major metabolite of ETBE, it is possible that TBA is the active toxic ...

journal_title：Toxicology and applied pharmacology

authors： Salazar KD,Brinkerhoff CJ,Lee JS,Chiu WA

更新日期：2015-11-01 00:00:00

abstract：:A liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS)-based metabolomics approach was employed to identify endogenous metabolites as potential biomarkers for thioacetamide (TAA)-induced liver injury. TAA (10 and 30mg/kg), a well-known hepatotoxic agent, was administered daily to male Sprague-Dawley (SD)...

journal_title：Toxicology and applied pharmacology

authors： Jeong ES,Kim G,Shin HJ,Park SM,Oh JH,Kim YB,Moon KS,Choi HK,Jeong J,Shin JG,Kim DH

更新日期：2015-10-15 00:00:00

abstract：:Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-i...

journal_title：Toxicology and applied pharmacology

authors： Babu D,Leclercq G,Goossens V,Remijsen Q,Vandenabeele P,Motterlini R,Lefebvre RA

更新日期：2015-10-15 00:00:00

abstract：:Perfluorooctane sulfonate (PFOS), an emerging persistent contaminant that is commonly encountered during daily life, has been shown to exert toxic effects on the central nervous system (CNS). However, the molecular mechanisms underlying the neurotoxicity of PFOS remain largely unknown. It has been widely acknowledged ...

journal_title：Toxicology and applied pharmacology

authors： Wang C,Nie X,Zhang Y,Li T,Mao J,Liu X,Gu Y,Shi J,Xiao J,Wan C,Wu Q

更新日期：2015-10-15 00:00:00

abstract：:Metals such as arsenic, cadmium, beryllium, and nickel are known human carcinogens; however, other transition metals, such as tungsten (W), remain relatively uninvestigated with regard to their potential carcinogenic activity. Tungsten production for industrial and military applications has almost doubled over the pas...

journal_title：Toxicology and applied pharmacology

authors： Laulicht F,Brocato J,Cartularo L,Vaughan J,Wu F,Kluz T,Sun H,Oksuz BA,Shen S,Peana M,Medici S,Zoroddu MA,Costa M

更新日期：2015-10-01 00:00:00

abstract：:The rapid development of high-volume horizontal hydraulic fracturing for mining natural gas from shale has posed potential impacts on human health and biodiversity. The produced flow back waters after hydraulic stimulation are known to carry high levels of saline and total dissolved solids. To understand the toxicity ...

journal_title：Toxicology and applied pharmacology

authors： Yao Y,Chen T,Shen SS,Niu Y,DesMarais TL,Linn R,Saunders E,Fan Z,Lioy P,Kluz T,Chen LC,Wu Z,Costa M,Zelikoff J

更新日期：2015-10-01 00:00:00

abstract：:Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg1 (Rg1), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of n...

journal_title：Toxicology and applied pharmacology

authors： Kwok HH,Chan LS,Poon PY,Yue PY,Wong RN

更新日期：2015-09-15 00:00:00

abstract：:Cadmium (Cd) is a common environmental toxicant and an established carcinogen. Epidemiological studies implicate Cd with human breast cancer. Low micromolar concentrations of Cd promote proliferation of human breast cancer cells in vitro. The growth promotion of breast cancer cells is associated with the activation of...

journal_title：Toxicology and applied pharmacology

authors： Song X,Wei Z,Shaikh ZA

更新日期：2015-08-15 00:00:00

abstract：:Dopamine (DA), a monoamine catecholamine neurotransmitter with antiangiogenic activity, stabilizes tumor vessels in colon, prostate and ovarian cancers, thus increases chemotherapeutic efficacy. Here, in the rat C6 glioma models, we investigated the vascular normalization effects of DA and its mechanisms of action. DA...

journal_title：Toxicology and applied pharmacology

authors： Qin T,Wang C,Chen X,Duan C,Zhang X,Zhang J,Chai H,Tang T,Chen H,Yue J,Li Y,Yang J

更新日期：2015-07-15 00:00:00

abstract：:Insulin resistance is a characteristic feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling. Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of the insulin signaling pathways, and its increased activity and expression are implicated in the pathogenesis of ...

journal_title：Toxicology and applied pharmacology

authors： Liu ZQ,Liu T,Chen C,Li MY,Wang ZY,Chen RS,Wei GX,Wang XY,Luo DQ

更新日期：2015-05-15 00:00:00

abstract：:In utero bisphenol A (BPA) exposure affects reproductive function in the first generation (F1) of mice; however, not many studies have examined the reproductive effects of BPA exposure on subsequent generations. In this study, pregnant mice (F0) were orally dosed with vehicle, BPA (0.5, 20, and 50 μg/kg/day) or diethy...

journal_title：Toxicology and applied pharmacology

authors： Ziv-Gal A,Wang W,Zhou C,Flaws JA

更新日期：2015-05-01 00:00:00

abstract：:Chronic hypertension induces vascular remodeling. The most important factor for hypertension treatment is reducing the risk of cardiovascular disease. OW1 is a novel imperatorin derivative that exhibits vasodilative activity and antihypertensive effects in two-kidney one-clip (2K1C) renovascular hypertensive rats. It ...

journal_title：Toxicology and applied pharmacology

authors： Zhou N,Zhang Y,Wang T,He J,He H,He L

更新日期：2015-04-15 00:00:00

abstract：:Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

journal_title：Toxicology and applied pharmacology

authors： Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

更新日期：2015-03-15 00:00:00

abstract：:The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bioactivation and detoxification reactions into account using Monte Carlo simulations. Depending on the metabolic route, v...

journal_title：Toxicology and applied pharmacology

authors： Al-Subeihi AA,Alhusainy W,Kiwamoto R,Spenkelink B,van Bladeren PJ,Rietjens IM,Punt A

更新日期：2015-03-01 00:00:00

abstract：:Over half of T cell acute lymphoblastic leukemia (T-ALL) patients have activating mutations in the Notch gene. Moreover, the contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) is a known carcinogen that mediates its toxicity through the aryl hydrocarbon receptor (AHR), and crosstalk between activated AHR and Notch...

journal_title：Toxicology and applied pharmacology

authors： Ahrenhoerster LS,Leuthner TC,Tate ER,Lakatos PA,Laiosa MD

更新日期：2015-03-01 00:00:00

abstract：:Chronic exposure to low lead concentration produces hypertension; however, the underlying mechanisms remain unclear. We analyzed the role of oxidative stress, cyclooxygenase-2-dependent pathways and MAPK in the vascular alterations induced by chronic lead exposure. Aortas from lead-treated Wistar rats (1st dose: 10 μg...

journal_title：Toxicology and applied pharmacology

authors： Simões MR,Aguado A,Fiorim J,Silveira EA,Azevedo BF,Toscano CM,Zhenyukh O,Briones AM,Alonso MJ,Vassallo DV,Salaices M

更新日期：2015-03-01 00:00:00

abstract：:Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and PBPK modeling to perform in vitro to in vivo extrapolation (IVIVE) of lindane neurotoxicity. Lindane cell and media concentrations...

journal_title：Toxicology and applied pharmacology

authors： Croom EL,Shafer TJ,Evans MV,Mundy WR,Eklund CR,Johnstone AF,Mack CM,Pegram RA

更新日期：2015-02-15 00:00:00

abstract：:Jaridonin, a novel diterpenoid from Isodon rubescens, has been shown previously to inhibit proliferation of esophageal squamous cancer cells (ESCC) through G2/M phase cell cycle arrest. However, the involved mechanism is not fully understood. In this study, we found that the cell cycle arrest by Jaridonin was associat...

journal_title：Toxicology and applied pharmacology

authors： Ma YC,Su N,Shi XJ,Zhao W,Ke Y,Zi X,Zhao NM,Qin YH,Zhao HW,Liu HM

更新日期：2015-01-15 00:00:00

abstract：:Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD disturbs basal and human chorionic gonadotropin (hCG)-induced steroidogenesis in rat Leydig cells. Reduction in mitochondria...

journal_title：Toxicology and applied pharmacology

authors： Fa S,Pogrmic-Majkic K,Samardzija D,Hrubik J,Glisic B,Kovacevic R,Andric N

更新日期：2015-01-01 00:00:00